From left to right
Yuri Legeev, Oleg Nikolaevich Darashkevich, A.M. Olovnikov, Eugene I Goufman
EIGA PHARMA ADVISORY BOARD
Dr. Leonard Hayflick was born on 20 May 1928 in Philadelphia, Pa. He received his Ph.D. at the University of Pennsylvania in 1956. After receiving a post-doctoral Fellowship for study at the University of Texas, Galveston, under the tutelage of the renowned cell culturist Prof. Charles M. Pomerat, he returned to Philadelphia, where he spent ten years as an Associate Member of the Wistar Institute and two years as an Assistant Professor of Research Medicine at the University of Pennsylvania.
In 1968 Dr. Hayflick was appointed Professor of Medical Microbiology at the Stanford University School of Medicine, Stanford, California. In 1982 he moved to the University of Florida, Gainesville, where he became Director of the Center for Gerontological Studies and Professor of Zoology in the College of Liberal Arts and Sciences and Professor of Microbiology and Immunology in the College of Medicine.
In 1988 Dr. Hayflick joined the faculty of the University of California, San Francisco where he is presently Professor of Anatomy. Dr. Hayflick is a member of numerous national and international scientific and public boards of directors and committees. He is now, or has been, on the Editorial Boards of more than ten professional journals. Dr. Hayflick was Editor-in-Chief of the international journal “EXPERIMENTAL GERONTOLOGY” for 13 years.
He is a member of twenty scientific and professional societies in which he has held several high offices including President of the Gerontological Society of America from 1982 to 1983. He was a founding member of the Council of the National Institute on Aging, NIH and Chairman of its' Executive Committee. He was a consultant to the National Cancer Institute and the World Health Organization, and is now a member of several scientific advisory boards. He was Chairman of the Scientific Review Board of the American Federation for Aging Research where he was also a Vice President and a Member of the Board of Directors.
Dr Michael B Fossel M.D., Ph.D
Michael B. Fossel, M.D., Ph.D. (born 1950, Greenwich, Connecticut) is a professor of clinical medicine at Michigan State University best known for his views on telomerase therapy as a possible treatment forcellular senescence. Fossel has appeared on many major news programs to discuss aging and appears regularly on National Public Radio (NPR). He is also a respected lecturer, author, and the founder and former editor-in-chief of the Journal of Anti-Aging Medicine (now known as Rejuvenation Research).
Prior to earning his M.D. at Stanford Medical School, Fossel earned a joint B.A. (cum laude) and M.A. in psychology at Wesleyan University and a Ph.D. in neurobiology at Stanford University. He is also a graduate of Phillips Exeter Academy. After graduating from medical school in 1981, he was awarded a National Science Foundation fellowship and taught at Stanford University.
In addition to his current position at Michigan State University, Fossel has lectured at the National Institute for Health, the Smithsonian Institution, and at various other universities and institutes in various parts of the world. Fossel is a fellow of the American College of Emergency Physicians, a member of the American Association for the Advancement of Science, the American Gerontological Society, the American Society on Aging, and the American Geriatrics Society, and serves on the board of directors for the American Aging Association.
Fossel has written numerous articles on aging and ethics for the Journal of the American Medical Association and In Vivo, and a book by Fossel entitled Reversing Human Aging was published in 1996. The book garnered favorable reviews from mainstream newspapers as well as Scientific American and has since been published in six languages. An academic textbook by Fossel entitled Cells, Aging, and Human Diseasewas published in 2004 by Oxford University Press.
Since his days as a teacher at Stanford University, Fossel has studied aging from a medical and scientific perspective with a particular emphasis on premature aging syndromes such as progeria, and since at least 1996 he has been a strong and vocal advocate of experimenting with telomerase therapy as a way of treating diseases, disorders, and syndromes such as progeria, Alzheimer's disease, atherosclerosis,osteoporosis, cancer, AIDS, and organic senescence (i.e., aging). However, he is careful to qualify his advocacy of telomerase therapy as being a potential treatment for these conditions rather than a "cure for old age" and a panacea for age-related medical conditions, albeit a potential treatment that could radically extend the maximum human life span and reverse the aging process in most people. Specifically, Fossel sees the potential of telomerase therapy as being a highly effective point of intervention in a wide variety of medical conditions.
EIGA PHARMA RESEARCH TEAM
A.M. Olovnikov, PhD
First name: Alexey
Middle name: Matveevich
EDUCATION
Graduated from Moscow State University (biochemistry).
PhD (1966) in Immunochemistry was made in Department of Immunology and Oncology (head of Dept was Prof. Lev A. Zilber) and granted by the Scientific Counsel of Gamaleya Institute for Epidemology and Microbiology of Academy of Medical Sciences of the USSR. Scientific supervisor was Prof. Aaron. E. Gurvich. Theme of Ph.D. Thesis: "The detection of antigens and antibodies using immunosorbents".
PROFESSIONAL APPOINTMENT
1959 Senior technician , then Junior Investigator in Gamaleya
Institute for Epidemology and Microbiology of Academy of Medical Sciences (Department of Immunology and Oncology and Laboratory of Antibody
biosynthesis. Then Senior researcher in the 2 Medical Institute and Institute for biological trials of chemical compounds Themes: Immunochemical diagnostics and antibody formation studies
and theoretical biology studies.
1977 Senior researcher in the Institute for Chemical Physics of Academy of Sciences of the USSR. Themes: Development of immunochemical techniques and theoretical biological studies.
1996 - present. Senior researcher, then Leading researcher in Institute of Biochemical Physics of Russian Academy of Sciences. Themes: Theoretical Biology studies.
Main directions of scientific investigations are as follows: generation and elaboration of hypotheses aimed at explanation of molecular and cellular mechanisms of main still unsolved questions of biology of aging, cell differentiation, morphogenesis, peculiarities of nuclear envelop functioning, regulation of infradian rhythms and control of the flow of biological time in organism.
A short outline of some Olovnikov’s scientific contributions
In 1971-1973, A.M. Olovnikov made an contribution into foundation of a biological area, that is called a telomere biology. The essence of this novel scientific direction consists in the study of mechanisms of shortening of telomeric DNA in normal somatic cells, as well as the study of the biological role of this shortening and pathways of maintenance of stability of chromosome tips in germline and somatic cells, stem cells and cancer cells including. These studies are now performed in dozens of labs around the world and they were started just after the wortldwide recognition of the existence of the process of telomeric DNA shortening which was firstly predicted in Olovnikov's theoretical publications. On the whole, A.M. Olovnikov performed in the telomere biology the following:
1) it was firstly formulated the very existence of the problem of the DNA
end underreplication (In 1971 , in Doklady, see in Bibliography);
2) it was explained that a circular form of genome of prokaryotes is a means of
protection of their DNA from the end underreplication;
3) it was predicted the existence of the process of DNA shortening at the tips of chromosomal DNA during doubling of normal somatic cells. On this basis, it was interpreted the existence of a Hayflick limit, or the restricted potential of doublings of the normally aging somatic cells;
4) it was predicted the existence of correlation between cellular senescence and telomere DNA shortening;
5) it was also predicted the existence of special form of compensatory DNA polymerase in germline cells (now it is called as a telomerase) which is responsible for the maintenance of the stable length of telomere DNA;
6) it was proposed that cancer cells should have the same DNA polymerase (telomerase) as the germline cells, and it was predicted that this DNA polymerase (that is a telomerase) does endow the cancer cells with their immortality, allowing them to avoid a Hayflick limit and cell senescence.
In 1992-1995, Olovnikov put forward, the conception of an another effect, namely so called "DNA terminal underrepair synthesis", or shortly "end underrepair".
In 1997-1999 Olovnikov proposed and theoretically elaborated the mechanism of quantitative regulation of genes’ expression via the so called fountain mechanism of RNA-dependent regulation of ion channels in inner membrane of nuclear envelope.
In 2003-2006, Olovnikov proposed the principally novel mechanism of biological aging (in frame of the so called redusome hypothesis) and then, on its basis, it was developed the hypothesis of a chronomere program of life span. Besides it was suggested an existence of novel physiological system, so called lunasensor system.
In 2007, it was proposed a new hypothesis concerning the origin of Alzheimer’s disease.
List of Olovnikov's publications
(some Russian publications were also published in English)
1. Гурвич А.Е., Оловников А.М. Сравнение антигенных свойств чистых антител и неспецифических гамма-глобулинов. Биохимия, том 25, вып. 4, 646-652 (1960).
2. Оловников А.М. Изготовление иммуносорбентов на основе эмульсионного неизотактического полистирола. Лабор. дело, № 8, 31-34 (1962).
3. Оловников А.М. Поликонденсированный суспензионный антитело-иммуносорбент и его использование в реакции агглютинации для определения содержания антигенов. ДАН СССР, том 158, № 5, 1202-1205 (1964).
4. Оловников А.М. Использование иммуносорбентов для определения абсолютных количеств гаптенов и антигенов. Биохимия, том 29, вып. 4, 680-684 (1964).
5. Оловников А.М. Получение иммуносорбентов в виде суспензии бензидин-белковых комплексов и использование их для определения антител методом агглютинации. Вопр. мед. химии, том 10, вып. 5, 538-542 (1964).
6. Оловников А.М. Определение содержания антигенов по агглютинации эритроцитов, покрытых поликонденсированными тетразотатом диаминодифениламина белками антисыворотки. ДАН СССР, том 169, № 5, 1180-1183 (1966).
7. Оловников А.М., Гурвич А.Е. Изучение антигенных свойств белково-целлюлозного иммуносорбента. Вопр. мед. химии, том 12, вып. 1, 112-115 (1966).
8. Olovnikov A.M., Gurvich A.E. Immunization with protein-cellulose co-polymer (immunosorbent). Nature, vol. 209, № 5021, 417- 419 (1966).
9. Olovnikov A.M. Sensitization of erythrocytes by polycondensed proteins of immune serum and their use for determining antigen content. Immunochemistry, 4, 77-80 (1967).
10. Оловников А.М. Методы иммунохимического анализа. ЖВХО им. Менделеева, том. 13, № 4, 445-452 (1968).
11. Оловников А.М. Определение содержания антигенов. Метод агглютинации ПБИС-эритроцитов и метод агглютинации частиц поликонденсированного антителоиммуносорбента. В книге: "Иммунохимичепский анализ", под ред. Л.А. Зильбера, Изд-во Медицина, Москва , стр. 68-78 (1968).
12. Оловников А.М., Цветков В.С. Обнаружение эмбрионального альфа-глобулина методом агрегат-гемагглютинации в сыворотке больных при некоторых формах рака человека. Бюлл. эксп. биол. мед. , том 68, №12,102-104 (1969).
13. Оловников А.М., А.А. Корукова. Использование стабильной соли тетразония для сенсибилизации белками эритроцитов при постановке локального пассивного гемолиза. Бюлл. эксп. биол. мед. , №12, 106-108 (1970).
14. Абелев Г.И., Цветков В.С., Бирюлина Т.И., Эльгорт Д.А., Оловников А.М., Гусев А.И., Язова А.К., Перова С.Д., Рубцов И.В., Шаборина С.В., Канторович Б.А., Тур В.М., Хазанов А.И.,Левина Д.М.. Оценка применения высокочувствительных методов определения альфа-фетопротеина для диагностики гепатоцеллюлярного рака и тератобластом. Бюлл. эксп. биол. мед. , № 4, 75-81 (1971).
15. Оловников А.М. Принцип маргинотомии в матричном синтезе полинуклеотидов. Доклады АН СССР, 201, № 6, 1496-1499 (1971). (Olovnikov A.M. (1971). Principles of marginotomy in template synthesis of
polynucleotides. Doklady Biochem. vol. 201, 394-397.).
16. Оловников А.М. Иммунный ответ и процесс маргинотомии в лимфоидных клетках. Вестник АМН СССР, № 12, 85-87 (1972).
17. Olovnikov, A.M. A theory of marginotomy: The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. vol. 41, 181-190 (1973).
18. Idelson L.I., Olovnikov A.M., Koifman M.M., Gorina L.I. Application of high sensitivity aggregate hemagglutination test for autoimmune hemolytic anemia with negative antiglobuline serum test. Vox sanguinis. № 6 (1976).
19. Горина Л.Г., Флуер Ф.С., Оловников А.М., Езепчук Ю.В. Высокочувствительное определение экзо-энтеротоксина Bacillus cereus методом агрегат-гемагглютинации. Журн. гиг. эпид.,микр. и иммунол. , том 20, № 3, 337-343 (1976).
20. Чирков С.Н., Оловников А.М., Сургучева Н.А., Оловникова Н.И., Пирузян Л.А., Кулинич А.В., Атабеков И.Г. Виробактериальная агглютинация (АБВ-тест)- новый метод иммунодиагностики вирусов сельскохозяйственных растений. Доклады ВАСХНИЛ. № 7, 9-11 (1981).
21. Чирков С.Н., Оловников А.М., Варицев Ю.А., Атабеков И.Г. Диагностика X, S, M и Y вирусов картофеля методом виробактериальной агглютинации. Сельскохозяйственная биология, том 17, № 2, 272-277 (1982).
22. Оловников А.М. Компьютена в механизме развития. Онтогенез, том 14, № 1, 106-107 (1983).
23. Chirkov S.N., Olovnikov A.M., Surguchyova N.I., Atabekov J.G. Immunodiagnosis of plant viruses by a virobacterial agglutination test. Ann. appl. Biol. , № 104, 477-483 (1984).
24. Оловников А.М., Койфман М.М., Оловникова Н.И. Гемобактериальная агглютинация - метод определения антиэритроцитарных антител. Бюлл. эксп. биол. мед. № 9, 373-375 (1985).
25. Оловников А.М. Старение есть результат укорочения "дифферотены" в теломере из-за концевой недорепликации и недорепарации ДНК. Известия АН СССР. Серия биол. № 4, 641-643 (1992).
26. Оловников А.М. Об эффекте концевой недорепарации, или неполной репарации конца линейной двуспиральной молекулы ДНК. Известия АН. Серия биол.,№4, 501-503 (1995).
27. Оловников А.М. О роли неполной репарации конца хромосомной ДНК в старении нейронов и постмитотических организмов. Известия РАН. Серия биол.,№4,504-507 (1995 ).
28. Оловников А.М. О возможности использования клетками эффекта концевой недорепарации ДНК в контроле за правильной последовательностью событий в индивидуальном развитии. Онтогенез , том 26, № 3, 254-256 (1995).
29. Оловников А.М. О парадоксе: малая продолжительность жизни при длинных теломерах . Онтогенез, том 26 , № 4, 332-334 (1995).
30. Olovnikov AM Telomeres, telomerase, and aging: origin of the theory. Experimental Gerontology, vol. 31, 443-448 (1996 )
31. Оловников А.М. Молекулярный механизм морфогенеза: теория локационной ДНК. Биохимия, том 61, № 11, 1948-1970 (1996).
32. Olovnikov AM (1997) Towards the quantitative traits regulation: fountain theory implications in comparative and developmental biology. Int. J. Dev. Biol. 41, 923-931.
33. Оловников А.М. (1998) Пседозатравки вызывают соматическое гипермутирование Ig-генов. Биохимия, 63(12):1702-1703.
34. Olovnikov A.M. (1999) The telomere shortening signal may be explained by a fountain mechanism modulating the expression of eukaryotic genes. J.Anti-Aging Medicine, 2 (1) 59-74.
35. Оловников А.М. (1999) Старение как универсальная хроническая “болезнь количественных признаков”: клеточное старение и РНК-зависимая ионная модуляция продуктивности генов. Успехи геронтологии (Санкт-Петербург), 3, 54-64.
36. Оловников А.М. (1999). Заметки о «принтомерном» механизме клеточной памяти и ионной регуляции конфигураций хроматина. Биохимия, 64, №12, 1689-1698.
37. Kipling D, Wynford-Thomas D, Jones CJ, Akbar A, Aspinall R, Bacchetti S, Blasco MA, Broccoli D, DePinho RA, Edwards DR, Effros RB, Harley CB, Lansdorp PM, Linskens MH, Prowse KR, Newbold RF, Olovnikov AM, Parkinson EK, Pawelec G, Ponten J, Shall S, Zijlmans M, Faragher RG . (1999). Telomere-dependent senescence. Nat Biotechnol 17(4):313-314.
38. Оловников А.М. (2001). Внутриядерные ионные фонтаны как регуляторы работы генома: фонтанная гипотеза доминантности и некоторых эпигенетических эффектов. Молекулярная биология. 35: 163-176.
39. Оловников А.М. (2003). Редусомная гипотеза старения и контроля биологического времени в индивидуальном развитии. Биохимия. 68 (1): 7-41. Olovnikov AM. The redusome hypothesis of aging and the control of biological time during individual development. Biochemistry (Mosc). 2003 Jan;68(1):2-33.
40. Оловников А.М. (2003). Редусомное старение: комментарии. Успехи геронтологии (СПб). 12: 28-45.
41. Olovnikov A. Role of Hypothetical Nuclear Organelles - Redusomes - in Morphogenesis, Aging and Cancer. (2004). In: Frontiers in Neurodegenerative Disorders and Aging: Fundamental Aspects, Clinical Perspectives and New Insights. Ozben T. and Chevion M. (Eds.), IOS Press, NATO Science Series. Series I: Life and Behavioural Sciences -Vol. 358, Pp. 89-98. Amsterdam, Berlin, Oxford. etc.
42. Оловников А.М. (2005) Принтомерная гипотеза морфогенеза: создавая эмбрион, клетки синтезируют транзиторные «перихромосомные» ДНК-содержащие органеллы, необходимые для интерпретации позиционной информации. Геофизические процессы и биосфера. том. 4., №1/2, 62-70.
43. Оловников А.М. Создавая эмбрион, клетки синтезируют транзиторные «перихромосомные» ДНК-содержащие органеллы, необходимые для интерпретации позиционной информации. В книге: "Химическая и биологическая кинетика. Новые горизонты. Том 2. Биологическая кинетика: Сб. обзорных статей". Москва, изд-во "Химия". (2005), 496-512.
44. Olovnikov A.M. (2005). When creating an embryo, cells are synthesizing transitory “perichromosomal” DNA-containing organelles necessary for interpreting positional information. Pp. 465-480. In: Chemical and Biological Kinetics New Horizons. Vol. 2: Biological Kinetics. In commemoration of Professor N.M. Emanuel's 90th Anniversary. Edited by E.B. Burlakova, S.D. Varfolomeev. Koninklijke Brill NV, Leiden, The Netherlands.
45. Оловников А.М. 2005. Редумера как недостающее звено в понимании старения человека. Клиническая геронтология. 11: 50-69.
46. Olovnikov A. Lunasensor, infradian rhythms, telomeres, and the chronomere program of aging. Annals of the New York Academy of Sciences. 2005, 1057: 112-132.
47. Olovnikov A. Chronobiology and chronomeres. In: Trends in Chronobiology Research. (Editor: Frank Columbus). 2006. Nova Science Publishers, Inc. New York. Pp.49-61.
48. Оловников А.М. Роль парагенома в развитии организмов. Онтогенез, 2007, том 38, № 2, с. 1-23.
49. Olovnikov A.M. Hypothesis: Lifespan is regulated by chronomere DNA of the hypothalamus. Journal of Alzheimer’s Disease. 2007, 11: 241-252.
Membership in Editorial boards of journals:
1) Advances in Gerontology (SPb, Russia);
2) Ontogenez (Russian Journal of Developmental Biology)(Russia)
3) Rejuvenation Research (editorial board)
4) Journal of Alzheimer’s disease (Associate Editor)
5) Current Aging Science (Bentham Science Publishers) (Associate Editor)
6) The Open Aging Journal (Bentham Science Publishers) (Associate Editor)
7) Current Gerontology and Geriatrics Research (Associate Editor)
PERSONAL
Marital status: Married, two sons
Place of birth: Vladivostok, Far East of Russia
Citizenship: Russia
Eugene I. Goufman
EDUCATION: M.D.: Semashko’s Moscow StateMedical Institute, 1980 Ph. D. in Cell Biology; Institute of Experimental Endocrinology, Academy of Medical Sciences of USSR,
PROFESSIONAL EXPERIENCE:
1999 – 2006 Orekhovich Institute of Biomedical Chemistry, department of proteomics, Russian Academy of Medical Sciences, Moscow, Russia
1995-1999 Visiting Scientist University of Illinois at Chicago Department of Genetics
Chicago, Illinois
1995-1997 Recipient of support from the NCI Oncology Research Faculty Development Program
1988-1994 Senior Staff Scientist Laboratory of Experimental Morphology Institute of Experimental Endocrinology, Russian Academy of Medical Sciences, Moscow
1983-1988 Ph.D. thesis research with Dr. Akmayev, Institute of Experimental Endocrinology, Academy of Medical Sciences of the USSR. Thesis title: the “Functional morphology of paraventricular nuclei under normal conditions and experimental disturbances of carbohydrate metabolism”
1981-1983 Post-graduate internship: Study of central neural regulation of the endocrine pancreas.
SUMMARY OF QUALIFICATIONS
· Experienced in tissue culture technology including culturing mammalian and insect cell lines.
· Experienced in introduction genes utilizing viruses , Lipofectins and calcium-mediated DNA transfection.
· Experienced in morphological, immuno-histochemical and serological techniques used to investigate pathomorphology of damaged tissues.
· Experienced in molecular biology techniques such as PCR, RT-PCR for cloning, site directed mutagenesis, and gel retardation assays, immunoprecipitation and western blot.
· Experienced in protein purification techniques and protein analysis using column chromatography and SDS-PAGE.
· Experienced in proteomics technics (2-D electrophoresis, chromatography, MALDI-TOFmass spectrometry).
PUBLICATIONS
1.Goufman EI, Moshkovskii SA, Tikhonova OV, Lokhov PG, Zgoda VG, Serebryakova MV, Toropygin IY, Vlasova MA, Safarova MR, Makarov OV, Archakov AI.
Two-dimensional electrophoretic proteome study of serum thermostable fraction from patients with various tumor conditions.
Biochemistry (Mosc). 2006 Apr;71(4):354-60.
2. Moshkovskii SA, Serebryakova MV, Kuteykin-Teplyakov KB, Tikhonova OV, Goufman EI, Zgoda VG, Taranets IN, Makarov OV, Archakov AI.
Ovarian cancer marker of 11.7 kDa detected by proteomics is a serum amyloid A1.
Proteomics. 2005 Sep;5(14):3790-7.
3. Govorun VM, Lokhov PG, Moshkovskii SA, Momynaliev KT, Selesnyova OV, Kudryavtseva LV, Serebryakova MV, Tikhonova OV, Goufman EI, Archakov AI.
Comparative analysis of different typing methods for Helicobacter pylori clinical isolates.
Biochemistry (Mosc). 2004 May;69(5):536-41.
4. Lokhov PG, Tikhonova OV, Moshkovskii SA, Goufman EI, Serebriakova MV, Maksimov BI, Toropyguine IY, Zgoda VG, Govorun VM, Archakov AI.
Database search post-processing by neural network: Advanced facilities for identification of components in protein mixtures using mass spectrometric peptide mapping.
Proteomics. 2004 Mar;4(3):633-42.
5. Makarov OV, Govorun VM, Taranets IN, Goufman EI, Gritsai AN, Archakov AI.
[Early proteomics in ovarian cancer: myth or reality?]
Biomed Khim. 2003 Jan-Feb;49(1):2-7. Review. Russian.
6. Govorun VM, Moshkovskii SA, Tikhonova OV, Goufman EI, Serebryakova MV, Momynaliev KT, Lokhov PG, Khryapova EV, Kudryavtseva LV, Smirnova OV, Toropyguine IY, Maksimov BI, Archakov AI.
Comparative analysis of proteome maps of Helicobacter pylori clinical isolates.
Biochemistry (Mosc). 2003 Jan;68(1):42-9.
7. Gartel AL, Ye X, Goufman E, Shianov P, Hay N, Najmabadi F, Tyner AL.
Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4510-5. Epub 2001 Mar 27.
8. Gartel AL, Goufman E, Najmabadi F, Tyner AL.
Sp1 and Sp3 activate p21 (WAF1/CIP1) gene transcription in the Caco-2 colon adenocarcinoma cell line.
Oncogene. 2000 Oct 26;19(45):5182-8.
9. Gartel AL, Najmabadi F, Goufman E, Tyner AL.
A role for E2F1 in Ras activation of p21(WAF1/CIP1) transcription.
Oncogene. 2000 Feb 17;19(7):961-4.
10. Gartel AL, Goufman E, Tevosian SG, Shih H, Yee AS, Tyner AL.
Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins.
Oncogene. 1998 Dec 31;17(26):3463-9.
11. Serfas MS, Goufman E, Feuerman MH, Gartel AL, Tyner AL.
p53-independent induction of p21WAF1/CIP1 expression in pericentral hepatocytes following carbon tetrachloride intoxication.
Cell Growth Differ. 1997 Sep;8(9):951-61.
12.Gartel AL, Serfas MS, Gartel M, Goufman E, Wu GS, el-Deiry WS, Tyner AL. Related
p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line.
Exp Cell Res. 1996 Sep 15;227(2):171-81.
13. Akmaev IG, Goufman EI, Gusev AA, Markellov VV.
[The previously unknown biological characteristics of the neurons of the paraventricular hypothalamic nucleus]
Fiziol Zh SSSR Im I M Sechenova. 1992 Sep;78(9):63-8. Russian.
14. Reznikov AG, Akmaev IG, Fidelina OF, Gorbatyuk OS, Goufman EI, Gusev AA, Kalimullina LB, Pivnitskii KK, Sergeev VG, Vikhreva OV.
Metabolism of testosterone in discrete regions of the brain of rat embryos.
Neurosci Behav Physiol. 1991 May-Jun;21(3):259-63..
15. Goufman EI.
Cellular organization of the paraventricular nuclei of the rat hypothalamus.
Neurosci Behav Physiol. 1991 May-Jun;21(3):210-5.
16.Goufman EI.
[Cellular organization of paraventricular hypothalamic nuclei of the rat]
Arkh Anat Gistol Embriol. 1990 Jun;98(6):46-52. Russian.
17. Reznikov AG, Akmaev IG, Fidelina OF, Gorbatiuk OS, Goufman EI, Gusev AA, Kalimullina LB, Pivnitskii KK, Sergeev VG, Vikhreva OV.
[Testosterone metabolism in discrete areas of the brain in rat fetuses]
Probl Endokrinol (Mosk). 1990 May-Jun;36(3):57-61. Russian.
18. Akmaev IG, Goufman EI.
Experimental evidence for hypothalamic paraventricular nucleus involvement in the regulation of carbohydrate homeostasis.
Biomed Sci. 1990 Feb;1(2):193-8.
19. Gorbatiuk OS, Goufman EI, Gusev AA, Starosel'tseva LK, Akmaev IG.
[Reaction of specific cell populations of hypothalamic paraventricular nuclei of the rat to carbohydrate loading and fasting]
Biull Eksp Biol Med. 1989 Jul;108(7):105-7. Russian.
20. Goufman EI.
[Topography of the subnuclei of the paraventricular hypothalamic nucleus in rats and the sensitivity of their neurons to insulin deficiency]
Biull Eksp Biol Med. 1985 Feb;99(2):194-6. Russian.
PARTICIPATION IN INTERNATIONAL MEETINGS
1. XI International Congress of Cytochemistry. Cell Biology and Imaging for the New Century. UK, 2000
2 . Proteomics Congress. Munchen, Germany, 2002
RESEARCH SUPPORT
COMPLETED and ACTIVE
1. Federal target scientifically technical program of the Ministry of the industry and science, Russia “Researches and development in priority directions of development of a science and technics”, The state contract № 43.106.11.0005 (principal investigator) with 2002 to 2004 г.
2. The agreement №С-02-2003 Regional public Fund of assistance to domestic medicine (principal investigator) with 2003 to 2004 г.
3. Federal target scientifically technical program of the Ministry of the industry and science, Russia “The state support of the centers of collective using” with 2005
Proteomics
Oleg Nikolaevich DARASHKEVICH
Date of birth: January 4,1954,Russia
Education: Graduated from Minsk State Medical Institute
1977
Post graduate study: Post graduate Course of Shemyakin Institute of Bioorganic Chemistry of the 1984 Academy of Sciences of USSR
Positions: Head of Project and General Director of Agro-Industrial Enterprise in Mogilev region of Belorus, suffered after Chernobyl Nuclear power plant disaster
Scientific adviser, Company Modus-Business, Minsk
Company SCIF, Bratislava.
Title: Ph.D in Medicine
Specialization Biochemistry, Biotechnology
Main publications
| № | Patent Application Number | Patent Number | Titel |
| Номер | Дата публ. | Номер | Дата публ. |
|  | 20000706 | 2002.03.30 |
|
| Device for continuous magnetic separation of liquid samples |
|  | 20000790 | 2002.03.30 | 6370 | 2004.09.30 | Magnetic separator |
|  | 20000791 | 2002.03.30 | 6766 | 2005.03.30 | Method for simultaneous detection of multiple components in the sample |
|  | 20000935 | 2002.06.30 |
|
| Device and method for magnetic concentration of components in liquid samples |
|  | 20030359 | 2004.12.30 |
|
| Method of sterilization of liquid samples |
| 6 | PCT/BY01/00011 | 2002.03.30 |
|
| Device for continuous magnetic separation of liquid samples |
| 7 | PCT/BY01/00014 | 2002.03.30 |
|
| A method and a device for simultaneous detection of multiple components in a mixture |
| 8 USA | 10/362,298 |
|
|
| A method and a device for simultaneous detection of multiple components in a mixture |
| 9 EP | ЕР1365241 |
|
|
| A method and a device for simultaneous detection of multiple components in a mixture |
| 10 ЕАПО |
|
| 004670 |
| Method and device for simultaneous detection of multiple components in the mixture |
| 11 ЕАПО |
|
| 004133 |
| Device for continuous magnetic separation of components in liquid mixtures |
| 12 РФ | 2003125218 |
| 2280395 |
| Method of sterilization of liquid samples |
| 13 | а20060719 |
|
|
| Способ исследования Method of investigationвозникновения злокачественного процесса в организме и тест-система для его осуществления |
| 14 | а20060916 |
|
|
| Способ лечения заболеваний с нарушением ангиогенеза и белковые комплексы для его осуществления (варианты) |
| 15 | а20061352 |
|
|
| Способ профилактики и лечения заболеваний с нарушением ангиогенеза и белковый комплекс для его осуществления |
| 16 | а20070027 |
|
|
| Способ лечения заболеваний с нарушением ангиогенеза |
| 17 | РСТ/ВУ2007/000002 |
|
|
| Protein Complexes for Prevention and Treatment of Diseases with Angiogenesis Disorders |
